We are currently recruiting for a Staff Research Associate (technician) position and looking for someone with mouse genotyping and mouse behavior experience. Please see job posting #9849 for Staff Research Associate I (9613C) on jobs.berkeley.edu.

Welcome to the Bateup Lab!

The ability of neurons to dynamically alter their activity in response to changes in the internal or external environment is fundamental to our brain's capacity to learn and adapt. Importantly, this remarkable plasticity must be balanced by mechanisms that ensure stable activity at the level of neural circuits. Understanding the molecular machinery that allows neurons to develop properly, dynamically alter their activity, and maintain balance is a fundamental goal of our research. Perturbations in synapse and circuit balance are associated with numerous neurological and psychiatric disorders, including epilepsy and autism spectrum disorder. A main focus of our laboratory is to understand how molecular changes associated with these diseases lead to altered neural development and activity. To address this, we are taking a multi-systems approach incorporating molecular, biochemical, electrophysiological, and behavioral analyses in mouse models and patient-derived human cells.

asd

Basal ganglia dysfunction in autism spectrum disorders

We are investigating how altered synaptic activity in basal ganglia circuits contributes to the behavioral manifestations of autism spectrum disorder.

Continue reading
modeling

Disease modeling with human brain organoids

We are using genetically engineered human neurons and brain organoids to study how mutations causing neurodevelopmental disorders affect early brain development.

Continue reading
mtor

Unraveling the complexity of neuronal mTOR signaling

We are using molecular profiling and biochemical approaches to define the up- and down-stream components of the mTOR pathway in neurons.

Continue reading
celltypes

Elucidating cell type diversity

We are exploring the genetic diversity of neuronal populations using single cell profiling.

Continue reading
Card image cap

August 21, 2020

Congratulations to PhD graduate John Blair!

Today we said farewell to Bateup lab all star John Blair! Congratulations John on earning your PhD. We look forward to great things in your post-doc and beyond!

Continue Reading
Card image cap

August 20, 2020

Bateup lab Zoom trivia

Celebrated John's thesis submission with a Bateup lab-themed Zoom trivia contest! John came up with some awesome questions!

Continue Reading
Card image cap

July 16, 2020

Webinar for the SynGAP Research Fund community

Helen gave a webinar for the SynGAP parent and research community on how loss of Syngap1 affects striatal synapses and behaviors in mice.

Continue Reading
Interferon-independent STING signaling promotes resistance to HSV-1 in vivo

Yamashiro LH, Wilson SC, Morrison HM, Karalis V, Chung J-YJ, Chen KJ, Bateup HS, Szpara ML, Lee AY, Cox JS, Vance RE

Nature Communications. July 7, 2020.

Tsc1-mTORC1 signaling controls striatal dopamine release and cognitive flexibility

Kosillo P, Doig NM, Ahmed KM, Agopyan-Miu AHCW, Wong CD, Conyers L, Threlfell S, Magill PJ, and Bateup HS

Nature Communications. November 28, 2019.

Genetically engineered human cortical spheroid models of tuberous sclerosis

Blair JD, Hockemeyer D, and Bateup HS

Nature Medicine. October 24, 2018.