Welcome to the Bateup Lab!

The ability of neurons to dynamically alter their activity in response to changes in the internal or external environment is fundamental to our brain's capacity to learn and adapt. Importantly, this remarkable plasticity must be balanced by mechanisms that ensure stable activity at the level of neural circuits. Understanding the molecular machinery that allows neurons to properly develop, dynamically alter their activity, and maintain balance is a fundamental goal of our research. Perturbations in synapse and circuit balance are associated with numerous neurological and psychiatric disorders, including epilepsy and autism spectrum disorder. A main focus of our laboratory is to understand how molecular changes associated with these diseases lead to altered neural development and activity. To address this, we are taking a multi-systems approach incorporating molecular, biochemical, electrophysiological, and behavioral analyses in mouse models and patient-derived human cells.

asd

Basal ganglia dysfunction in autism spectrum disorders

We are investigating how altered synaptic activity in basal ganglia circuits contributes to the behavioral manifestations of autism spectrum disorder.

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modeling

Disease modeling with human brain organoids

We are using genetically engineered human neurons and brain organoids to study how mutations causing neurodevelopmental disorders affect early brain development.

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mtor

Unraveling the complexity of neuronal mTOR signaling

We are using molecular profiling and biochemical approaches to define the up- and down-stream components of the mTOR pathway in neurons.

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celltypes

Elucidating cell type diversity

We are exploring the genetic diversity of neuronal populations using single cell profiling.

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Villy's manuscript is posted on bioRxiv!

July 23, 2021

Villy's paper on the effects of Raptor and Rictor deletion in mouse models of TSC is out on bioRxiv!

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Polina's review article is out in Frontiers in Neural Circuits!

July 23, 2021

Polina's review discussing dopaminergic dysregulation in mouse models of syndromic autism spectrum disorders is out in Frontiers! Part of a special topic on "Dopamine Neuron Diversity in Circuits and Diseases"

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Welcome Khaja!

June 8, 2021

Welcome to our new post-doc Khaja Syed!

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Dopaminergic Dysregulation in Syndromic Autism Spectrum Disorders: Insights From Genetic Mouse Models

Kosillo P and Bateup HS

Frontiers in Neural Circuits. July 23, 2021.

Generation of a DAT-P2A-Flpo mouse line for intersectional genetic targeting of dopamine neuron subpopulations

Kramer DJ, Aisenberg EE, Kosillo P, Friedmann D, Stafford DA, Lee AY-F, Luo L, Hockemeyer D, Ngai J, and Bateup HS

Cell Reports. May 11, 2021.

Current approaches and future directions for the treatment of mTORopathies

Karalis V and Bateup HS

Developmental Neuroscience. April 29, 2021.