Welcome to the Bateup Lab!

The ability of neurons to dynamically alter their activity in response to changes in the internal or external environment is fundamental to our brain's capacity to learn and adapt. Importantly, this remarkable plasticity must be balanced by mechanisms that ensure stable activity at the level of neural circuits. Understanding the molecular machinery that allows neurons to both be dynamic and maintain balance is a fundamental goal of our research. Perturbations in synapse and circuit balance are associated with numerous neurological and psychiatric disorders, including epilepsy and autism spectrum disorder. A main focus of our laboratory is to understand how molecular changes associated with these diseases lead to altered neural development and activity. To address this, we are taking a multi-systems approach incorporating molecular, biochemical, electrophysiological, and behavioral analyses in mouse models and patient-derived human cells.

asd

Basal ganglia dysfunction in autism spectrum disorders

We are investigating how altered synaptic activity in basal ganglia circuits contributes to the behavioral manifestations of autism spectrum disorder.

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modeling

Disease modeling with human brain organoids

We are using genetically engineered human neurons and brain organoids to study how mutations causing neurodevelopmental disorders affect early brain development.

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mtor

Unraveling the complexity of neuronal mTOR signaling

We are using molecular profiling and biochemical approaches to define the up- and down-stream components of the mTOR pathway in neurons.

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celltypes

Elucidating cell type diversity

We are exploring the genetic diversity of neuronal populations using single cell profiling.

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June 29, 2020

New lab pre-print on bioRxiv!

Dan's manuscript describing the generation and characterization of DAT-Flp mice is up on bioRxiv!

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June 19, 2020

Congrats to Adela on successfully defending her Master's thesis!

Congrats to Adela for submitting and defending her Master's thesis at Sorbonne Universite. It was great to host her in our lab as a visiting scholar, even if only for a short time!

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May 16, 2020

Congrats to honors graduates Emily Chen and Darain Noveir!

Congratulations to MCB undergraduates Emily Chen and Darain Noveir for finishing their honors theses! Also congrats to Darain on winning the MCB Outstanding Scholar Award! It was great to have you both in the lab, we wish you all the best in your future careers!

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Tsc1-mTORC1 signaling controls striatal dopamine release and cognitive flexibility

Kosillo P, Doig NM, Ahmed KM, Agopyan-Miu AHCW, Wong CD, Conyers L, Threlfell S, Magill PJ, and Bateup HS

Nature Communications. November 28, 2019.

Genetically engineered human cortical spheroid models of tuberous sclerosis

Blair JD, Hockemeyer D, and Bateup HS

Nature Medicine. October 24, 2018.