Welcome to the Bateup Lab!

The ability of neurons to dynamically alter their activity in response to changes in the internal or external environment is fundamental to our brain's capacity to learn and adapt. Importantly, this remarkable plasticity must be balanced by mechanisms that ensure stable activity at the level of neural circuits. Understanding the molecular machinery that allows neurons to properly develop, dynamically alter their activity, and maintain balance is a fundamental goal of our research. Perturbations in synapse and circuit balance are associated with numerous neurological and psychiatric disorders, including epilepsy and autism spectrum disorder. A main focus of our laboratory is to understand how molecular changes associated with these diseases lead to altered neural development and activity. To address this, we are taking a multi-systems approach incorporating molecular, biochemical, electrophysiological, and behavioral analyses in mouse models and patient-derived human cells.

asd

Basal ganglia dysfunction in autism spectrum disorders

We are investigating how altered synaptic activity in basal ganglia circuits contributes to the behavioral manifestations of autism spectrum disorder.

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modeling

Disease modeling with human brain organoids

We are using genetically engineered human neurons and brain organoids to study how mutations causing neurodevelopmental disorders affect early brain development.

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mtor

Unraveling the complexity of neuronal mTOR signaling

We are using molecular profiling and biochemical approaches to define the up- and down-stream components of the mTOR pathway in neurons.

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celltypes

Elucidating cell type diversity

We are exploring the genetic diversity of neuronal populations using single cell profiling.

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Congrats to honors graduate Raina Jaing!

December 11, 2020

Congratulations to Raina Jaing on completing her undergrad honors thesis and graduating this fall! We wish you all the best in your future endeavors!

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Bipan recieves TS Alliance fellowship

December 1, 2020

Congratulations to Bipan for receiving a one-year postdoctoral fellowship from the Tuberous Sclerosis Alliance!

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Helen has been promoted to Associate Professor with tenure!

November 4, 2020

Congratulations to the members of the Bateup lab, past and present, on all of your accomplishments!

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Interferon-independent STING signaling promotes resistance to HSV-1 in vivo

Yamashiro LH, Wilson SC, Morrison HM, Karalis V, Chung J-YJ, Chen KJ, Bateup HS, Szpara ML, Lee AY, Cox JS, Vance RE

Nature Communications. July 7, 2020.

Tsc1-mTORC1 signaling controls striatal dopamine release and cognitive flexibility

Kosillo P, Doig NM, Ahmed KM, Agopyan-Miu AHCW, Wong CD, Conyers L, Threlfell S, Magill PJ, and Bateup HS

Nature Communications. November 28, 2019.

Genetically engineered human cortical spheroid models of tuberous sclerosis

Blair JD, Hockemeyer D, and Bateup HS

Nature Medicine. October 24, 2018.