Bateup Lab Publications

A multimodal cell census and atlas of the mammalian primary motor cortex

BRAIN Initiative Cell Census Network (BICCN)

Nature. October 6, 2021

Loss of Tsc1 from striatal direct pathway neurons impairs endocannabinoid-LTD and enhances motor routine learning

Benthall KN, Cording KC, Agopyan-Miu AHCW, Wong CD, Chen EY and Bateup HS

Cell Reports. August 10, 2021

Dopaminergic Dysregulation in Syndromic Autism Spectrum Disorders: Insights From Genetic Mouse Models

Kosillo P and Bateup HS

Frontiers in Neural Circuits. July 23, 2021.

PMID: 34366796

The convergence of two signaling pathways within the striatum reveals potential mechanisms of neuropsychiatric disease

Cording KR and Bateup HS

Biological Psychiatry. June 1, 2021.

PMID: 34016376

Generation of a DAT-P2A-Flpo mouse line for intersectional genetic targeting of dopamine neuron subpopulations

Kramer DJ, Aisenberg EE, Kosillo P, Friedmann D, Stafford DA, Lee AY-F, Luo L, Hockemeyer D, Ngai J, and Bateup HS

Cell Reports. May 11, 2021.

PMID: 33979604

Current approaches and future directions for the treatment of mTORopathies

Karalis V and Bateup HS

Developmental Neuroscience. April 29, 2021.

PMID: 33910214

Interferon-independent STING signaling promotes resistance to HSV-1 in vivo

Yamashiro LH, Wilson SC, Morrison HM, Karalis V, Chung J-YJ, Chen KJ, Bateup HS, Szpara ML, Lee AY, Cox JS, Vance RE

Nature Communications. July 7, 2020.

PMID: 32636381

Tsc1-mTORC1 signaling controls striatal dopamine release and cognitive flexibility

Kosillo P, Doig NM, Ahmed KM, Agopyan-Miu AHCW, Wong CD, Conyers L, Threlfell S, Magill PJ, and Bateup HS

Nature Communications. November 28, 2019.

PMID: 31780742

New frontiers in modeling tuberous sclerosis with human stem cell-derived neurons and brain organoids

Blair JD and Bateup HS

Developmental Dynamics. May 9, 2019.

PMID: 31070828

Genetically engineered human cortical spheroid models of tuberous sclerosis

Blair JD, Hockemeyer D, and Bateup HS

Nature Medicine. October 24, 2018.

PMID: 30127391

Corticostriatal Transmission Is Selectively Enhanced in Striatonigral Neurons with Postnatal Loss of Tsc1

Benthall KN, Ong SL, Bateup HS

Cell Reports. June 12, 2018.

PMID: 29898392

Nucleus Accumbens Subnuclei Regulate Motivated Behavior via Direct Inhibition and Disinhibition of VTA Dopamine Subpopulations

Yang H, de Jong JW, Tak Y, Peck J, Bateup HS, Lammel S.

Neuron. January 17, 2018.

PMID: 29307710

Widespread Translational Remodeling during Human Neuronal Differentiation

Blair JD, Hockemeyer D, Doudna JA, Bateup HS, Floor SN.

Cell Reports. November 14, 2017.

PMID: 29141229

Voltage-sensitive rhodol with enhanced two-photon brightness

Kulkarni RU, Kramer DJ, Pourmandi N, Karbasi K, Bateup HS, Miller EW.

PNAS. March 14, 2017.

PMID: 28242676

Establishment of Genome-edited Human Pluripotent Stem Cell Lines: From Targeting to Isolation

Blair JD, Bateup HS, Hockemeyer DF.

Journal of Visualized Experiments: JoVE. February 2, 2016.

PMID: 26863600

Bateup Lab bioRxiv Preprints

Raptor downregulation rescues neuronal phenotypes in mouse models of Tuberous Sclerosis Complex

Karalis V, Caval-Holme F, Bateup HS

bioRxiv. Posted July 23, 2021.

A multimodel cell census and atlas of the mammalian primary motor cortex

BRAIN Initiative Cell Census Network (BICCN)

bioRxiv. Posted October 21, 2020.

Generation of a DAT-Flp mouse line for intersectional genetic targeting of dopamine neuron subpopulations

Kramer DJ, Kosillo P, Friedmann D, Stafford D, Luo L, Lee AY-F, Hockemeyer D, Ngai J, Bateup HS

bioRxiv. Posted June 29, 2020.

Update Now published in Cell Reports: doi.org/10.1016/j.celrep.2021.109123

Loss of Tsc1 from striatal direct pathway neurons impairs endocannabinoid-LTD and enhances motor routine learning

Benthall KN, Cording KR, Agopyan-Miu AHCW, Chen EY, Bateup HS

bioRxiv. Posted December 16, 2019.

Update Now published in Cell Reports: doi.org/10.1016/j.celrep.2021.109511

STING controls Herpes Simplex Virus in vivo independent of type I interferon induction

Yamashiro LH, Wilson SC, Morrison HM, Karalis V, Chung J-YJ, Chen KJ, Bateup HS, Szpara ML, Lee AY, Cox JS, Vance RE

bioRxiv. Posted December 13, 2019.

Update Now published in Nature Communications: doi.org/10.1038/s41467-020-17156-x

Tsc1-mTOR signaling controls the structure and function of midbrain dopamine neurons

Kosillo P, Doig NM, Agopyan-Miu AHCW, Ahmed KM, Conyers L, Threlfell S, Magill PJ, and Bateup HS

bioRxiv. Posted July 25, 2018.

Update Now published in Nature Communications: doi.org/10.1038/s41467-019-13396-8

Widespread translational remodeling during human neuronal differentiation

Blair JD, Hockemeyer D, Doudna JA, Bateup HS, Floor SN

bioRxiv. Posted June 26, 2017.

Update Now published in Cell Reports: doi.org/10.1016/j.celrep.2017.10.096

Dr. Bateup's post-doctoral publications (with Dr. Bernardo Sabatini at Harvard Medical School)

Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons

Li Y, Wang H, Muffat J, Cheng AW, Orlando DA, Lovén J, Kwok SM, Feldman DA, Bateup HS, Gao Q, Hockemeyer D, Mitalipova M, Lewis CA, Vander Heiden MG, Sur M, Young RA, Jaenisch R

Cell Stem Cell. October 3, 2013.

PMID: 24094325

Temporal dynamics of a homeostatic pathway controlling neural network activity

Bateup HS, Denefrio CL, Johnson CA, Saulnier JL, Sabatini BL

Frontiers in Molecular Neuroscience. September 18, 2013.

PMID: 24065881

Excitatory/inhibitory synaptic imbalance leads to hippocampal hyperexcitability in mouse models of tuberous sclerosis

Bateup HS, Johnson CA, Denefrio CL, Saulnier JL, Kornacker K, Sabatini BL.

Neuron. May 8, 2013.

PMID: 23664616

Loss of Tsc1 in vivo impairs hippocampal mGluR-LTD and increases excitatory synaptic function

Bateup HS, Takasaki KT, Saulnier JL, Denefrio CL, Sabatini BL

The Journal of Neuroscience. June 15, 2011.

PMID: 21677170

For synapses, it's depression not death

Bateup HS, Sabatini BL

Cell. May 28, 2010.

PMID: 20510921

Dr. Bateup's graduate school publications (with Dr. Paul Greengard at Rockefeller University)

For Paul (an obituary for Paul Greengard)

Bateup HS, Heiman M, Schaefer A

Nature Neuroscience. July 1, 2019.

Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors

Bateup HS, Santini E, Shen W, Birnbaum S, Valjent E, Surmeier DJ, Fisone G, Nestler EJ, Greengard P

PNAS. August 17, 2010.

PMID: 20682746

Role of adrenoceptors in the regulation of dopamine/DARPP-32 signaling in neostriatal neurons

Hara M, Fukui R, Hieda E, Kuroiwa M, Bateup HS, Kano T, Greengard P, Nishi A

Journal of Neurochemistry. May 11, 2010.

PMID: 20236221

Regulation of DARPP-32 phosphorylation by three distinct dopamine D1-like receptor signaling pathways in the neostriatum.

Kuroiwa M, Bateup HS, Shuto T, Higashi H, Tanaka M, Nishi A

Journal of Neurochemistry. November 10, 2008.

PMID: 18823371

Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum

Nishi A, Kuroiwa M, Miller DB, O'Callaghan JP, Bateup HS, Shuto T, Sotogaku N, Fukuda T, Heintz N, Greengard P, Snyder GL

The Journal of Neuroscience. October 15, 2008.

PMID: 18923023

Cell type-specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs

Bateup HS, Svenningsson P, Kuroiwa M, Gong S, Nishi A, Heintz N, Greengard P

Nature Neuroscience. August 11, 2008.

PMID: 18622401

Involvement of AMPA receptor phosphorylation in antidepressant actions with special reference to tianeptine

Svenningsson P, Bateup H, Qi H, Takamiya K, Huganir RL, Spedding M, Roth BL, McEwen BS, Greengard P

The European Journal of Neuroscience. December 26, 2007.

PMID: 18088278

Cellular localization and function of DARPP-32 in the rodent retina

Witkovsky P, Svenningsson P, Yan L, Bateup H, Silver R

The European Journal of Neuroscience. June 25, 2007.

PMID: 17552992

Quantitative analysis of protein phosphorylation in mouse brain by hypothesis-driven multistage mass spectrometry

Jin M, Bateup H, Padovan JC, Greengard P, Nairn AC, Chait BT

Analytical Chemistry. December 15, 2005.

PMID: 16351129

Maternal separation suppresses TGF alpha mRNA expression in the prefrontal cortex of male and female neonatal C57BL/6 mice

Romeo RD, Fossella JA, Bateup HS, Sisti HM, Brake WG, McEwen BS

Brain Research. Developmental Brain Research. August 18, 2004.

PMID: 15283997

Dr. Bateup's undergraduate publications (with Dr. Douglas Granger at Penn State University)

Testosterone, cortisol, and women's competition.

Bateup HS, Booth A, Shirtcliff EA, Granger DA.

Evolution and Human Behavior. May 23, 2002.

PMID: 31780742