Welcome to the Bateup Lab!

The ability of neurons to dynamically alter their activity in response to changes in the internal or external environment is fundamental to our brain's capacity to learn and adapt. Importantly, this remarkable plasticity must be balanced by mechanisms that ensure stable activity at the level of neural circuits. Understanding the molecular machinery that allows neurons to properly develop, dynamically alter their activity, and maintain balance is a fundamental goal of our research. Perturbations in synapse and circuit balance are associated with numerous neurological and psychiatric disorders, including epilepsy and autism spectrum disorder. A main focus of our laboratory is to understand how molecular changes associated with these diseases lead to altered neural development and activity. To address this, we are taking a multi-systems approach incorporating molecular, biochemical, electrophysiological, and behavioral analyses in mouse models and patient-derived human cells.

Basal ganglia dysfunction in autism spectrum disorders

We are investigating how altered synaptic activity in basal ganglia circuits contributes to the behavioral manifestations of autism spectrum disorder.

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Disease modeling with human brain organoids

We are using genetically engineered human neurons and brain organoids to study how mutations causing neurodevelopmental disorders affect early brain development.

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Unraveling the complexity of neuronal mTOR signaling

We are using molecular profiling and biochemical approaches to define the up- and down-stream components of the mTOR pathway in neurons.

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Elucidating cell type diversity

We are exploring the genetic diversity of neuronal populations using single cell profiling.

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Bateup lab at the 2021 Neuro retreat

October 8, 2021

Fun to be back in person, listening to great science at the retreat

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Villy gives a talk at the Neuro retreat

October 8, 2021

Congrats to Villy on a great talk!

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The BICCN "flagship" paper is out in Nature!

October 6, 2021

Congrats to alum Dr. Dan Kramer for his work on this massive collaborative project!

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A multimodal cell census and atlas of the mammalian primary motor cortex

BRAIN Initiative Cell Census Network (BICCN)

Nature. October 6, 2021.

Loss of Tsc1 from striatal direct pathway neurons impairs endocannabinoid-LTD and enhances motor routine learning

Benthall KN, Cording KC, Agopyan-Miu AHCW, Wong CD, Chen EY and Bateup HS

Cell Reports. August 10, 2021.

Dopaminergic Dysregulation in Syndromic Autism Spectrum Disorders: Insights From Genetic Mouse Models

Kosillo P and Bateup HS

Frontiers in Neural Circuits. July 23, 2021.